Backed by 3 clinical trials and 60 years of German prescription use — the first formula that actually restores nerve function instead of masking the pain.
Best Seller
#1 Choice For Neuropathy Of Any Kind
2 Stabilized R-ALA 600mg - Advanced Nerve Support for Burning, Tingling & Numbness
$23.99
$39.99
Summer Sale - 40% off
- Reduces burning and numbness in 3-5 weeks
- Targets nerve damage at the root
- Pure R-Form, the version clinical trials actually used
- Slow-release capsule, feeds your nerves all day long
- 600mg clinical dose — not the underdosed version
- Clean, vegan and third-party tested
3rd-Party Test Results
Independent laboratory testing
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Order now and ships by :
August 11th
Trusted by 5K+ customers
who choose Root of Nature to finally feel like themselves again.
How to use
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Take 3 capsules once daily with a meal— breakfast or lunch is ideal. That's the full 600mg clinical dose of stabilized R-Alpha Lipoic Acid your nerves need, delivered the way German doctors have prescribed it for decades.
Our slow-release capsule is designed to absorb well even when taken with food, so you don't have to worry about timing it perfectly — and it's gentle on the stomach. Take it daily without skipping. The trials that backed this formula measured results over weeks and months of consistent use, not days. Stay with it.
Can R-ALA help with non-diabetic neuropathy?
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R-ALA isn’t exclusive to people with diabetes. It supports the body’s antioxidant defenses and healthy nerve function, so it may also be relevant for neuropathy caused by other factors.
However, most clinical research has focused on diabetic peripheral neuropathy, while evidence for other types of neuropathy is still limited and mixed.
Are there any side effects?
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R-ALA is generally well tolerated, and most people take it without any issues. Unlike standard capsules that release the entire dose at once, our slow-release granules deliver R-ALA gradually. This is designed to be gentler on the stomach and help minimize occasional digestive discomfort. Individual tolerance can still vary.
Because R-ALA may lower blood sugar, speak with your healthcare provider if you take blood-sugar-lowering medication.
What about Stomach Burning?
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Some standard ALA supplements may cause occasional stomach burning or heartburn because the full dose is released at once.
Our capsules use slow-release granules, which gradually release the R-ALA instead of dumping the entire dose into your stomach at once.
This is designed to be gentler on the stomach and minimize digestive discomfort. Most people tolerate R-ALA well, although individual responses can vary.
Ingredients
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Each capsule contains 200mg of stabilized R-Alpha Lipoic Acid in its pure R-form — the biologically active form your nerve cells actually recognize. Delivered in a coconut oil base for maximum fat-soluble absorption. No fillers. No proprietary blends. No racemic S-form that blocks the active ingredient from doing its job. What you see on the label is exactly what is in the capsule at the exact dose the clinical trials used.
How long before I notice a difference?
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R-ALA is not an instant pain reliever—it works best when taken consistently.
In clinical studies of oral alpha-lipoic acid for diabetic neuropathy, improvements were assessed after approximately 3–5 weeks.
Some people may notice changes sooner, while others may require longer, and results vary from person to person.
60-Day Guarantee
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We offer a 60-day money-back guarantee. If you don't feel a meaningful difference after consistent use we will refund you in full — no questions asked.
Shipping & Returns
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We offer tracked shipping on all orders.
All orders are processed by our careful fulfilment team within 24 business hours.
We are currently experiencing high volume of orders so delivery times, depending on your location, range from 5-13 business days.
We've made returning products super easy. Simply contact us support@rootofnature.com and we'll handle everything.
Results You Can Feel in Your Body
2 Stabilized R-ALA 600mg - Advanced Nerve Support for Burning, Tingling & Numbness
Three Major Trials. Three Continents. One Result.
ALADIN (1995) — 82.5% Response Rate
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The first major trial of R-Alpha Lipoic Acid for diabetic nerve concerns.
328 patients across multiple research centers received either 600mg of R-ALA or a placebo.
The result:"82.5% of patients in the 600mg group reported meaningful symptom improvement, compared to 57.6% on placebo.
"Total Symptom Scores dropped by 63.5% in the R-ALA group. Published in Diabetologia, Ziegler et al.
SYDNEY 2 (2006) — Relief in 5 Weeks
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The trial that proved oral R-ALA works — not just IV delivery.
181 diabetic patients took 600mg of R-ALA daily for 5 weeks.
Researchers reported"significant improvements in neuropathic symptoms and deficits" with the 600mg oral dose, establishing it as the optimal balance of efficacy and tolerability. Published in Diabetes Care, Ziegler et al.
NATHAN 1 (2011) — 4 Years of Sustained Use
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The longest and largest trial of R-ALA ever conducted.
460 patients across 36 research centers in the US, Canada, and Europe took 600mg of R-ALA daily for 4 full years.
Researchers concluded R-ALA produced"clinically meaningful improvement and prevention of progression of neuropathic impairments" over the duration of the study. Published inDiabetes Care, Ziegler et al.
Across All Three Trials, R-ALA Was Shown to:
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Improve Symptoms in as Little as 5 Weeks
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Deliver an 82.5% Response Rate
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Reduce Total Symptom Scores by 63.5%
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Halt Progression Over 4 Years of Use
What Real Customers Are Saying
Jimmy,
58
Verified Buyer
"I was on gabapentin for 4 years. Gained 35 pounds, could not think straight at work, and my feet were still burning every single night. My doctor kept increasing the dose and nothing changed. I started researching on my own and found out about the R-form versus the regular ALA I had already tried. Ordered Root of Nature, took it every night at 600mg. After about 3 weeks the burning started quieting down. I actually slept 6 hours straight for the first time in years. I stopped taking it for a month just to test it. Symptoms came back within 2 weeks. Started again and within 10 days I was sleeping again. That test told me everything I needed to know. I am off gabapentin completely now. My head is clear, I am down 18 pounds just from dropping the drug, and I can finally feel the floor under my feet in the morning without dreading the day."
Tim,
51
Verified Buyer
"I was diagnosed with peripheral neuropathy at 48 and I spent three years thinking this was just my life now. The burning was making it impossible to do my job. I tried every supplement on Amazon. Nerve Renew, B vitamins, standard alpha lipoic acid, nothing touched it. My neurologist offered gabapentin and I refused because I watched what it did to my patients. I started reading about the R-form versus racemic ALA and it was the first thing that actually made sense to me scientifically. Why had I been taking a supplement where half the capsule was working against the other half. I ordered Root of Nature and took it consistently for 5 weeks. The tingling in my feet started fading around week three. By week five I was completing full shifts without counting down the hours until I could sit down. I am not pain free but I am functional again and for the first time in three years I actually believe this is not going to keep getting worse."
Linda,
64
Verified Buyer
"I had not been down on the floor with my granddaughter in 3 years. The burning in my feet was so bad at night I barely slept and during the day I just sat and watched her play. My daughter kept telling me to try something new but I had already tried everything. A friend mentioned Root of Nature R-ALA and honestly I ordered it thinking it would be the same story. Six weeks later I was sitting on the floor building blocks with her. I cried the whole time. My husband thought something was wrong. Nothing was wrong. Everything was finally right."
What To Expect - Your Path Back To Feeling Like Yourself
Most solutions promise overnight results. We will tell you the truth instead.
Week 1-2
Building your Stores
R-ALA begins entering your nerve cell mitochondria and neutralizing the oxidative damage that has been building up. Most people do not feel dramatic changes yet. Some report a slight reduction in burning intensity at night. Your nerves are beginning to rebuild their defense system for the first time.
Week 3-4
Something is different. You can't explain it yet.
This is where most people notice the first real shift. The burning that kept you up at night starts to quiet. The tingling becomes less constant. Several customers report sleeping through the night for the first time in years during this window. The clinical trials showed measurable improvement beginning at week 3.
Week 5-8
Movement gets easier
Sustained daily movement becomes easier. Less planning around the pain. Less checking how bad it is before getting out of bed. The oxidative cascade that was progressing every single day begins to slow down meaningfully.
Beyond 8 Weeks
The day you stop checking how bad it is
The NATHAN 1 trial showed that consistent daily use over 4 years halted neuropathy progression entirely. The goal is not just relief. It is stopping the damage from spreading any further. Every day you continue is a day the window stays open.
The Only Choice That Actually Works
Gabapentin has been the first prescription for nerve pain since 1993. Over 30 years later millions are still suffering. Root of Nature was built because that was never good enough.
The Only Choice That Actually Works
Gabapentin has been the first prescription for nerve pain since 1993. Over 30 years later millions are still suffering. Root of Nature was built because that was never good enough.
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Root of Nature
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Pure R-Form Only
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Full 600mg Clinical Dose
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Stabilized Form
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Fat-Soluble Delivery
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No Stomach Burning
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60-Day Money-Back Guarantee
We're so confident in the quality of our product that we offer a satisfaction guarantee. If you're not completely satisfied with your purchase, simply return the item within 60 days for a full refund.
Add to Cart
100% Satisfaction
Fast Shipping
Easy Returns
60-Day Money-Back Guarantee
We're so confident in the quality of our product that we offer a satisfaction guarantee. If you're not completely satisfied with your purchase, simply return the item within 60 days for a full refund.
Add to Cart
100% Satisfaction
Fast Shipping
Easy Returns
Frequently Asked Questions
Find answers to common questions about our products, shipping, returns, and more.
How is this different from every other supplement I've tried?
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Most "Alpha Lipoic Acid" sold in America — including the top sellers at GNC, Walmart, and Amazon — is the cheap racemic form: a 50/50 mix of the natural R-form your body actually uses and a synthetic S-form that competes for the same cellular receptors and may block the R-form from doing its job. That's the version most people try, feel nothing from, and write off as "ALA doesn't work." Root of Nature is pure stabilized R-ALA at 600mg per day — the exact form and dose used in the three landmark clinical trials and the same dose German doctors have been prescribing since 1966. It's delivered in a coconut oil softgel for fat-soluble absorption, which also resolves the acid reflux and nausea that stop most people from sticking with standard ALA.
Does it actually work or is this just good marketing?
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Fair question — and one we'd be asking too. Don't take our word for it. Take the clinical data. In the ALADIN I trial, 82.5% of patients taking 600mg of R-ALA daily reported meaningful improvement in neuropathic symptoms versus 57.6% on placebo. The number-needed-to-treat for ALA is 2.7 — compared to gabapentin's 7.2 — meaning ALA is roughly 2.5 times more likely to help per patient than the drug 73 million Americans are currently prescribed. Three trials (ALADIN, SYDNEY 2, NATHAN 1) across hospitals in the U.S., Canada, and Europe — plus 60 years of prescription use in Germany — built that record. We didn't run those studies. Root of Nature simply makes sure the formula matches the dose and form they used.
How long before I feel something?
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We want to be straight with you, because you've probably been burned by promises before. The published clinical trials measured meaningful improvement at around 3 to 5 weeks of daily oral use.
Some people report a change earlier — within 1 to 2 weeks — others take longer, especially if neuropathy has been progressing for years.
The NATHAN 1 trial, which ran 4 years, showed continued benefit and prevention of progression with long-term use — meaning Root of Nature works best taken consistently, not judged after a week and quit.
Give it at least 60 days at the full 600mg dose before you decide.
I'm worried about side effects.
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Reasonable concern, especially if gabapentin or Lyrica is what you're comparing it to.
R-ALA's side-effect profile is genuinely cleaner — no brain fog, no weight gain, no dependency, no withdrawal.
The most common complaint with standard ALA is GI upset (acid reflux, nausea) when taken on an empty stomach, which is exactly why Root of Nature is delivered in a coconut oil slow release capsule.
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