The Science

The science behind your R-ALA

Clinically studied. Prescribed in Germany since 1966.

Not feeling it yet? That’s normal. R-ALA takes a little time to do its work. Here’s what the clinical trials found, and what it means for you.

Show me the studies
  • ✓600mg a day, the dose used in 3 landmark clinical trials
  • ✓Prescribed by German doctors since 1966
  • ✓Pure R-form, stabilized and third-party tested
Root of Nature R-Alpha Lipoic Acid 600mg

How the studies worked

Real trials. Real patients.

Not marketing claims. Three major clinical trials at universities across the US, Canada and Europe.

600mg

Every day

The same daily dose of alpha lipoic acid that’s in your R-ALA.

Blind

Double-blind

Neither the patients nor the researchers knew who got what. No wishful thinking.

100s

Of patients

Hundreds of patients took part across the three trials.

4 years

The longest study

The NATHAN 1 study followed its patients for four full years.

The results

What the trials found

ALADIN trial
82.5%

of patients reported meaningful improvement

In a double-blind clinical trial, 82.5% of patients taking 600mg of ALA daily reported meaningful improvement in neuropathic symptoms.

Reported meaningful improvement82.5%

More than 8 out of 10 patients on 600mg a day.

ALADIN I, double-blind clinical trial, 600mg of alpha lipoic acid daily.

Clinical trials
3–5 weeks

until improvement showed up

In the clinical trials, improvement showed up after 3 to 5 weeks of taking it by mouth. That’s why the first few weeks can feel quiet.

Week 1
Week 2
Week 3
Week 4
Week 5

If you’re in your first weeks, you’re right on schedule.

Oral alpha lipoic acid, 600mg daily.

NATHAN 1 trial
4 years

of 600mg, every single day

In the NATHAN 1 study, patients took 600mg every single day for four years, and the progression of their neuropathy was stopped.

Year 1600mg daily
Year 2600mg daily
Year 3600mg daily
Year 4600mg daily

Nobody in that study was judged after three weeks.

NATHAN 1, four-year clinical trial, 600mg of alpha lipoic acid daily.

What this means for you

Great results take consistency

Your body doesn’t store R-ALA. It doesn’t build up like a vitamin you can bank. It works while you keep taking it, every day. That’s the whole reason your subscription exists: so you never run out.

Your new normal. It holds as long as you keep going. Day 1Day 15Day 30Day 60Day 90+
Days 1–60

The building phase

It works quietly from day one. Around day 16 or 17, most people feel the first real change. Then the protection stacks up, week after week.

Day 90 and after

Your new normal

Quieter nights. More good days. And it holds as long as you keep taking it. Stop, and it comes back.

Why the R-form matters

Only one form fits

Most alpha lipoic acid sold in the US is a 50/50 mix of two mirror-image forms. Only the R-form is the one your nerve cells recognize. The other half competes for the same spots and can get in the way.

Inside your nerve cells, R-ALA works as an antioxidant and helps recharge the body’s own antioxidants, like vitamin C, vitamin E, glutathione and CoQ10. That’s why your R-ALA is pure R-form, stabilized, at 600mg.

Most ALA on the shelf
50% R + 50% S

Half of every capsule is the form your nerve cells don’t use.

Your R-ALA
100% R-form, 600mg

Stabilized, single ingredient, third-party tested.

The facts

60 years of medical use

1966

Prescribed in Germany

In Germany, doctors have prescribed alpha lipoic acid since 1966. It’s backed by real clinical trials and a long track record, not by a trend.

What’s inside, what’s not

Inside

600mg of stabilized R-alpha lipoic acid, pure R-form, in a slow-release capsule. One ingredient. No blends, nothing hidden.

Left out

GMO-free and gluten-free.

Tested

Lab tested by a third party, so you know what’s in the bottle.

Give it the time the studies did

Stay on track

Most people stop right before it gets good. Keep your subscription going, and if your timing doesn’t fit, change how often it comes instead of stopping.

Every order is covered by our 60-day money-back guarantee.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The study results describe the clinical trials named above; individual results may vary.